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MET IOP’s New Frontiers
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Dr. Abha Doshi, Principal – MET IOP along with MET Pharmacy
students at the ‘10th International Symposium’ |
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Dr. Abha Doshi, Sneha Ramaswamy and Prerna Malwadkar from MET Institute of Pharmacy presented a research paper on "NOVEL CONTROLLED RELEASE OF NORFLOXACIN BY FLOATING DRUG DELIVERY SYSTEMS" in Tenth International Symposium organised by Controlled release Society, Indian Chapter on 17th February 2010.
Norfloxacin is a synthetic antibiotic commonly used for the treatment of gonorrhoea, prostrate and urinary tract infections. However, due to the low gastric residence time, the bioavailability is compromised and in turn, number of doses are increased. Floating drug delivery system helps in targeting the drug to the stomach or the upper part of the intestine. This floating ability of the system increases the gastric residence time of the drug. The three layered tablets were prepared in which the controlled release layer was sandwiched between two floating layers. The controlled release layer contained HPMC polymer and floating layer contained sodium bicarbonate as gas generating agent. The formulation was found to have increased residence time with satisfactory mucoadhesion.
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